2-[1-[2-Cyclopropyl-2-oxo-1-phenylethyl]-4-Mercapto-3-piperidinylidene]acetic Acid Hydrochloride
2-[2-(Acetyloxy)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]-1-cyclopropyl-2-phenylethanone
CAS: 1391053-53-4;1391194-45-8
Molecular Formula: C20H21NO3S
2-[1-[2-Cyclopropyl-2-oxo-1-phenylethyl]-4-Mercapto-3-piperidinylidene]acetic Acid Hydrochloride - Names and Identifiers
2-[1-[2-Cyclopropyl-2-oxo-1-phenylethyl]-4-Mercapto-3-piperidinylidene]acetic Acid Hydrochloride - Physico-chemical Properties
| Molecular Formula | C20H21NO3S |
| Molar Mass | 355.45064 |
| Melting Point | >120°C (dec.) |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | Off-White to Pale Yellow |
| Storage Condition | Hygroscopic, Refrigerator, Under Inert Atmosphere |
| Stability | Hygroscopic |
2-[1-[2-Cyclopropyl-2-oxo-1-phenylethyl]-4-Mercapto-3-piperidinylidene]acetic Acid Hydrochloride - Reference Information
| overview | prasugrel hydrochloride (Prasugrel) is an oral antiplatelet drug jointly developed by Eli Lilly and its first pharmaceutical company. it was approved for listing in the European union and the United States in 2009. It is used to reduce thrombotic cardiovascular events (including in-stent thrombosis) in patients with acute coronary syndrome who will receive percutaneous coronary intervention. Prasugrel, chemical name: 5-[(1RS)-2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6, 7-tetrahydrothieno [3,2-c] pyridine-2-acetate. The synthetic route of prasugrel in the existing technology is mainly the original synthetic route of Japan's Sankyo company, using o-fluorobromobenzyl as the starting material, making it into a format reagent and condensing it with cyclonitrile to obtain 1-cyclopropyl -2-(2-fluorophenyl) ethanone, and then bromating it at the α position, and then substituting it with 2-thiophene and pyridine, the obtained product is acetylated to obtain prasugrel. In the process of synthesis according to the above process, a new unknown impurity without fluorine prasugrel was found in one of the batch of pilot scale-up prasugrel raw material detection patterns, which is not an intermediate of the above reaction. Therefore, it is necessary to study the new impurities of prasugrel. |
Last Update：2024-04-09 02:00:03
![2-[1-[2-Cyclopropyl-2-oxo-1-phenylethyl]-4-Mercapto-3-piperidinylidene]acetic Acid Hydrochloride](http://res.chembk.com/assets/images/structure/CB82621801.gif)
Supplier List
Spot supply
Product Name: Prasugrel EP Impurity A Visit Supplier Webpage Request for quotationCAS: 1391194-45-8
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: Prasugrel EP Impurity A Visit Supplier Webpage Request for quotationCAS: 1391194-45-8
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
View History
2-[1-[2-Cyclopropyl-2-oxo-1-phenylethyl]-4-Mercapto-3-piperidinylidene]acetic Acid Hydrochloride
2-(氨基磺酰基)苯硼酸
阿齐沙坦中间体(A2甲酯)
Stavudine Impurity 10
Medetomidine RC7
4α,5α-Isopropylidenedioxy-2β-hydroxycyclopentane-1β,3β-dicarboxylic acid hydrogen 1-methyl ester
4-溴-3-氟氰苯
6-硝基苯并二氢吡喃-4-酮
Acetic acid, [2-[2-(2-aminoethoxy)ethoxy]ethoxy]-
氨基Ε酸(1-萘氨-3,8-二磺酸)
2-(氨基磺酰基)苯硼酸
阿齐沙坦中间体(A2甲酯)
Stavudine Impurity 10
Medetomidine RC7
4α,5α-Isopropylidenedioxy-2β-hydroxycyclopentane-1β,3β-dicarboxylic acid hydrogen 1-methyl ester
4-溴-3-氟氰苯
6-硝基苯并二氢吡喃-4-酮
Acetic acid, [2-[2-(2-aminoethoxy)ethoxy]ethoxy]-
氨基Ε酸(1-萘氨-3,8-二磺酸)